Those who know me, know how much I love Lex Fridman's podcast. By no means "The Best" episode –cannot pick that really– but my first exposure was the episodes with Jim Keller. just Great! Have listened to them a couple of times since then, and every time learned something new
Here are some clips, but do check the full episodes: Most People Don't Think Simple Enough Abstraction Layers from the Atom to the Data Center